As the demand for next-generation natural products, precision biosynthesis, and novel antibiotics rises, the limitations of conventional microbial hosts become more apparent. While E. coli and Bacillus excel in protein expression, they fall short in handling large, complex biosynthetic gene clusters (BGCs) or producing high-value secondary metabolites. Enter Streptomyces coelicolor—a soil-dwelling actinomycete with extraordinary genetic […]