Strain Development Services
Accelerate your biologics program with Elise’s end-to-end strain and cell-line development platform. From AI-guided chassis design through master-bank creation, we engineer hosts—microbial or mammalian—to hit your titer, quality, and timeline goals.
Precision Chassis & Vector Engineering
- AI-Driven Host Selection
• In silico modeling matches physiology (growth rate, secretion, metabolism) to your molecule - Custom Expression Vectors
• Optimized promoters, RBS, and copy-number control for maximal yield
• Dual-vector and operon designs for multi-subunit or bispecific formats
Mammalian Cell Line Development
Our EPIC-2BOX workflow delivers high-performance CHO and HEK hosts under GS or DHFR selection.
- Supported Cell Lines
• CHO-K1, CHOZN®, CHO-DG44
• HEK293, NS0
• Custom host inquiries welcome - Transient Expression
• Up to 20 L single-use scale for rapid material supply - Stable Clone Generation
• 8-week lead time to top clones
• Guaranteed ≥ 3 g/L mAb titer—otherwise free strain replacement - Research Cell Banking & Stability
• Master & working banks with full safety, identity, and stability panels
• STR fingerprinting, mycoplasma, viral-safety testing
Microbial Strain Development
Proof-of-concept through pilot, our microbial platform covers E. coli, Pichia, Saccharomyces, and beyond.
- Bacterial Hosts
• E. coli BL21(DE3), Origami 2(DE3), Rosetta 2(DE3), HMS 174(DE3) - Yeast & Fungal Hosts
• Pichia pastoris, Saccharomyces cerevisiae - ALE & Synthetic Biology
• Adaptive Laboratory Evolution for stress tolerance and flux redirection
• CRISPR-aided pathway tuning to boost target product
Integrated Process Development
- Design of Experiments (DoE) — Six Sigma and QbD frameworks define CPPs and CQAs
- High-Throughput Screening — 1,200 clones/day with automated ELISA, qPCR, HPLC
- Scale-Up Correlation — Validated from microwell to 10 L single-use reactors
- Tech Transfer — Complete CMC tech-pack and regulatory documentation for seamless GMP transfer
Infrastructure & Digital Insight
| Facility | Scale | Output | Features |
|---|---|---|---|
| Discovery Pods | 0.5–10 mL (×24) | 200 DoE runs/month | Inline fluorescence, automated feeding, high-throughput robotics |
| Pilot Suites | 1–20 L single-use | Up to 10 g/L product | BSL-2, pH/DO PID loops, digital-twin modeling |
| Clinical GMP | 50–500 L stainless | 1–20 kg clinical material | ISO 7 suites, segregated up/downstream |
| Commercial Trains | 1,000–10,000 L | 100 kg–metric ton | Redundant utilities, SCADA 4.0, continuous perfusion options |
All systems link to our 24/7 command center for real-time deviation management by fermentation engineers and data scientists.
Engagement Models
- Lead‐Candidate Sprint
Chassis design → vector build → 20-clone screen → lead strain in 8 weeks - Scale-Up & Tech-Transfer
Pilot batches in 100–1,000 L; gap analysis & engineering runs in 30 days - Dedicated Cell-Bank Lease
Reserved master/working bank and screening capacity for ongoing pipelines - On-Demand Pilot Slots
Pay-as-you-go access to 1–20 L runs for rapid iteration
Quality, Compliance & Sustainability
- Certifications: ISO 9001, ISO 13485, FDA-registered
- Data Integrity: 21 CFR Part 11 e-records, audit-ready archives
- Green Initiatives: 100 % renewable power by Q4 2025; closed-loop water recycling
- Supply Resilience: Multi-site cell-bank storage; dual-sourced critical raw materials
Contact our Team Today!
Transform your strain concept into a commercial reality—first time, every time.