From milligrams to multigrams—scalable, high-quality biologics for research and discovery.
At Elise Biopharma, we provide fast, flexible CDMO services tailored for research tool companies, assay developers, and catalog reagent providers. Whether you’re producing recombinant proteins for an antibody kit, synthesizing mRNA for a biosensor platform, or scaling up a difficult-to-express enzyme, our team delivers precise manufacturing support from concept to commercialization.
Our microbial and mRNA platforms are optimized for rapid expression, high-yield production, and lot-to-lot reproducibility—making them ideal for RUO-grade reagents that require technical excellence without GMP pricing.
We help our clients scale efficiently—moving seamlessly from milligram R&D batches to multi-gram or even kilogram-scale production—while maintaining the purity, activity, and quality that your end users demand.
Supporting Discovery, Diagnostics, and Tools That Matter
We understand the unique needs of reagent developers: fast turnarounds, small-to-mid batch volumes, and performance reliability. Whether you’re a catalog supplier, diagnostics firm, CRO, or bioassay innovator, we can help.
We support:
- Reagent companies expanding catalog offerings or improving COGs
- Bioassay developers scaling new biosensor or affinity-based kits
- Diagnostics firms needing non-GMP proteins or enzymes for RUO/IVD kits
- Synthetic biology platforms requiring reproducible bioactives for development pipelines
- Academic technology transfer teams converting novel reagents into scalable products
Elise Biopharma offers the speed of a startup with the infrastructure of a serious CDMO, enabling researchers and tool companies to move faster with quality and consistency.
CDMO Capabilities for Research Tools & Reagents
Recombinant Protein Expression with Tag Optimization
We specialize in producing proteins that are difficult to express or purify:
- Structural or disordered proteins
- Thermolabile enzymes
- Multi-domain or fusion constructs
We support:
- N- or C-terminal tags: His, GST, MBP, FLAG, etc.
- Protease cleavage sites for tag removal
- Solubility and folding optimization
- Low-endotoxin purification for clean assay signals
Whether you’re building an assay standard or custom tool, we deliver stability, activity, and lot consistency.
mRNA Synthesis for Research-Grade Payloads
Our mRNA platform is designed for non-GMP synthesis of capped, polyadenylated, and QC-verified mRNA for:
- Biosensor development
- CRISPR/Cas9 tool delivery
- Therapeutic prototyping
- Synthetic circuits and gene switches
We offer:
- IVT with CleanCap®, ARCA, or custom capping
- Column or magnetic-bead purification
- Nanodrop, fragment analysis, and agarose QC
- Sequence verification and yield reporting
Affinity Reagents & Biosensor Components
We produce highly specific biological parts for advanced detection systems:
- scFvs, nanobodies, and Fab fragments
- Fluorescent tags or conjugation-ready domains
- Reporter enzymes (e.g. HRP, luciferase)
- Chimeric biosensor proteins with linkers, spacers, or surface domains
These are ideal for diagnostics, spatial biology, flow cytometry, and point-of-care assays.
Custom Fermentation Development
We support strain optimization and fermentation tuning for:
- Novel enzymes or protein variants
- Unusual host strains (E. coli, Pichia, or custom chassis)
- Soluble vs. inclusion body tradeoffs
- High-cell-density fermentation strategies
- Small-batch fermentors: 2L, 10L, 50L scale
We help you determine optimal media, expression conditions, and yield for short- and long-term reagent production.
Fast-Turnaround Pilot Lots for Catalog or Kit Reagents
Time is everything when launching a new reagent. We offer:
- Pilot batch production with <3 week turnaround
- Full documentation (CoA, SDS, sequence data)
- Repeatable manufacturing processes for future re-orders
- Temperature-sensitive logistics for protein stability
Our team ensures you get production-ready materials fast—whether for validation studies, product launch, or inventory restock.
Why Research Tool Developers Choose Elise Biopharma
We act as an extension of your lab, offering technical clarity, rapid execution, and commercial foresight.
What sets us apart:
- Rapid onboarding — Kick off in <2 weeks
- Transparent pricing — RUO-grade cost structures with premium quality
- Flexible batch sizes — mg to multigram scale
- Analytics included — QC tailored to reagent application
- Scientist-to-scientist communication — Our technical team speaks your language
Our clients return to us because we don’t just manufacture — we enable discovery at scale.
Let’s Bring Your Reagents to Market
Whether you’re scaling a top-selling catalog protein, producing bespoke components for a spatial omics platform, or testing mRNA tools in a new context, Elise Biopharma can help.