At Elise Biopharma, precision fermentation isn’t just a process—it’s a core expertise. We pride ourselves on scaling the production of both wild-type and recombinant microorganisms, enabling breakthroughs in healthcare, biotechnology, industrial bioprocessing, and beyond. Our commitment to flexibility and innovation means we can seamlessly adapt to client needs, whether you’re a start-up investigating novel biomolecules or a large-scale manufacturer seeking reliable, high-volume production.
Fermentation Infrastructure
- Fermentor Range: 20L to 14,500L
We maintain an extensive range of fermentors, from pilot-scale (20L) to commercial scale (14,500L). This diversity lets us optimize runs for everything from small-batch R&D to large-scale manufacturing campaigns. - HEPA-Filtered Suites
Every fermentation suite features HEPA filtration, minimizing contamination risk and ensuring product purity. This level of cleanliness is particularly crucial when working with sensitive or high-value strains. - Mobile Fermentation Systems
- Benchtop Systems (2–10L): Ideal for early-stage development, strain optimization, and proof-of-concept research.
- Freestanding Systems (20–100L): Bridging the gap between bench-scale and full production, these pilot systems enable precise scale-up trials before moving to larger vessels.
Automated Process Control
- Real-time Monitoring
Our automated systems continuously track critical parameters such as pH, temperature, dissolved oxygen, pressure, and foam levels. This granular data ensures each fermentation run is closely managed to optimize yield and product quality. - Off-line Monitoring
In addition to real-time sensors, we use specialized analytics—like glucose and lactate monitors—to fine-tune metabolic activity, enabling tighter control over growth conditions and productivity. - PLC Controller with Cascading Control
Our programmable logic controllers (PLCs) allow for advanced control strategies that automatically adjust aeration, agitation, and vessel pressure. By cascading these control loops, we maintain an optimal environment throughout each stage of the fermentation cycle.
Key Applications
- Enzymes & Proteins: From industrial enzymes to therapeutic proteins, our precision fermentation approach ensures high-titer expression.
- Recombinant Proteins: We specialize in producing recombinant proteins in systems like E. coli and Bacillus subtilis, with the flexibility to accommodate custom strains.
- Custom Fermentation Projects: We partner with clients on specialized applications, offering tailored support for everything from protocol development to final production.
Why Choose Elise Biopharma for Precision Fermentation?
- Scalability & Flexibility
With a wide fermentor range and modular systems, we tailor production to each stage of your project—no unnecessary overscale or lost efficiency. - Clean & Controlled Environments
Our HEPA-filtered fermentation suites and rigorous quality management systems align with ISO 13485, ISO 9001, and FDA standards, ensuring a contamination-free process. - Cutting-edge Automation
Our state-of-the-art process control and monitoring tools create a highly reliable environment, reducing variation and maximizing consistency in product quality. - Expert Team
Backed by seasoned scientists and engineers, we bring decades of fermentation experience to troubleshoot challenges and optimize your process from start to finish. - Integrated Services
Beyond fermentation, Elise Biopharma supports downstream processing, analytical testing, and final product formulation—offering a true end-to-end solution under one roof.
Partner with Elise Biopharma
Whether you’re looking to develop a new therapeutic enzyme, scale an existing protein process, or explore novel biomaterials, our precision fermentation team is ready to help you achieve your goals. At Elise Biopharma, we combine deep expertise and advanced infrastructure to deliver consistent, high-quality results—time after time.
Ready to take the next step?
Get in touch with our precision fermentation specialists to discuss your project requirements, request a quote, or learn more about our comprehensive capabilities. Let’s work together to transform your innovative ideas into tangible, market-ready solutions.