At Elise Biopharma, we understand that getting from cell paste to a finished, high-purity product involves more than just fermentation. Our end-to-end bioprocessing services ensure every step— from cell harvesting to final fill—is optimized for maximum yield and product integrity. By combining advanced equipment, decades of expertise, and strict quality standards, we deliver reliable solutions tailored to your exact specifications.
Core Downstream Capabilities
- Centrifugation & Filtration
- AS-26 Super Sharples & Disc Stack Centrifuges: High-throughput, efficient biomass and solids separation for large-scale production runs.
- Tangential Flow Filtration (TFF) Units: Ideal for concentration and diafiltration of proteins, enzymes, and other biomolecules, maintaining high purity.
- Homogenization
- SPX Homogenizers: Our robust homogenizers ensure efficient cell disruption and product release, achieving optimal recovery of intracellular proteins, enzymes, or other target molecules.
- Chromatography
- Packed Bed Chromatography Systems (50 mL to 50 L): Designed for targeted purification, our chromatography platforms accommodate multiple resin types and custom purification protocols.
- Additional Services
- Final-Fill Operations: We handle the last steps in-house or through qualified vendor partnerships, ensuring a seamless path from bulk product to finished format.
- Freeze-Drying & Liquid Formulation: Tailored to preserve the stability and bioactivity of your product, whether in lyophilized or liquid form.
- Tech Transfer: Our experienced team facilitates smooth scale-ups to 10,000L fermentors, transferring your process from bench to commercial scale with minimal risk.
Why Choose Elise Biopharma for Custom Bioprocessing?
- End-to-End Solutions
We integrate every stage—from initial harvest to final formulation—under one roof, streamlining timelines and reducing complexity. - Advanced Equipment & Expertise
Our state-of-the-art centrifuges, TFF units, homogenizers, and chromatography systems are operated by a team with extensive experience in both R&D and commercial production. - Quality & Compliance
With ISO 13485, ISO 9001, and FDA registrations, our processes meet global regulatory standards. We maintain rigorous quality controls to ensure reliability and consistency in every batch. - Scalability & Flexibility
Whether you require pilot-scale purification or large-scale production, our adaptable infrastructure and methods can be customized to your specific requirements. - Collaborative Approach
We don’t just provide services—we become an extension of your team. Our scientists and engineers work closely with you to optimize yields, troubleshoot challenges, and meet critical milestones.
Typical Applications
- Therapeutic Proteins: Extracting and purifying recombinant proteins and enzymes for clinical or research use.
- Diagnostic Reagents: Processing raw materials to create high-purity enzymes for in-vitro diagnostic (IVD) applications.
- Industrial Biotech: Generating large volumes of enzymes or biomolecules for use in food processing, biofuels, or other industrial processes.
Partner with Elise Biopharma
When you choose Elise Biopharma for custom bioprocessing and downstream processing, you gain a trusted partner dedicated to delivering high-quality, cost-effective solutions. Our commitment to innovation, compliance, and customer service ensures that every project is executed with the utmost professionalism and care.
Ready to streamline your bioprocessing needs?
Contact our team to learn more about our comprehensive capabilities, request a quote, or begin planning your next production run. Let Elise Biopharma help transform your raw materials into market-ready products—efficiently and reliably.