At Elise Biopharma, we innovate to accelerate groundbreaking biologics and therapeutics, transforming scientific insights into life-changing treatments. We’re seeking passionate, skilled individuals to join our dynamic team.
Current Job Openings:
Senior Scientist, Upstream Process Development
Position Summary:
Senior Scientists at Elise Biopharma are highly motivated leaders who supervise multiple projects, mentor junior scientists, and significantly contribute to the strategic growth and operational success of the company. This role specifically focuses on the development and optimization of mammalian upstream processes.
*Bilingual strongly preferred (French)
Responsibilities:
- Provide expert technical leadership for designing, planning, and executing experiments focused on mammalian cell culture, upstream bioprocess development, and optimization.
- Supervise bioreactor setup, operation, troubleshooting, and routine maintenance.
- Ensure consistency, reproducibility, and reliability of upstream processes.
- Independently analyze and interpret experimental data; document and communicate findings effectively through comprehensive reports and scientific presentations.
- Collaborate closely with global teams; international travel for project-related activities will be required.
- Stay abreast of scientific literature, emerging technologies, and methodologies relevant to cell culture and bioprocessing.
- Lead the assessment and integration of innovative technologies and methodologies, evaluating their potential impact on business and scientific outcomes.
- Provide guidance, mentorship, and technical coaching to junior staff, promoting a high-performance team culture.
- Assist management with resource allocation, project scheduling, and strategic planning.
- Ensure strict adherence to laboratory safety guidelines, environmental regulations, and good manufacturing practices (GMP).
Qualifications:
- Ph.D., Master’s, or Bachelor’s degree in biology, biochemistry, biomedical/biochemical engineering, or a related scientific field.
- Ph.D. with ≥2 years, Master’s with ≥5 years, or Bachelor’s with ≥8 years of experience in mammalian upstream process development, scale-up, and GMP manufacturing.
- Proven hands-on experience operating bioreactors, including bench-scale and pilot-scale systems.
- Strong knowledge of mammalian cell lines (CHO DG44, CHOK1, HEK293, NS0, PerC6).
- Expertise in media development, feed strategy optimization, and cell line productivity enhancement.
- Solid experience with analytical techniques (cell counting, viability assays, metabolite profiling).
- Experience in design-of-experiment (DOE) methodologies and statistical analysis software (JMP, Minitab, Design Expert).
- Strong troubleshooting and problem-solving skills, capable of addressing complex upstream processing issues.
- Effective communication, organizational skills, and ability to work collaboratively in cross-functional teams.
- Proficiency with Microsoft Office (Excel, Word, PowerPoint).
- Ability to multitask efficiently and prioritize effectively in a fast-paced environment.
- Flexible, innovative, and results-driven with strong business acumen.
Senior Scientist, Downstream Process Development
Position Summary:
Senior Scientists at Elise Biopharma drive innovative research and development efforts in downstream processing, leading teams to optimize purification processes, improve product quality, and facilitate scale-up to manufacturing. They mentor junior team members and collaborate extensively with cross-functional teams to achieve company objectives.
*Bilingual strongly preferred (French)
Responsibilities:
- Lead technical planning, design, and execution of experiments focused on downstream process development, including chromatography, filtration, and purification techniques.
- Manage setup, operation, troubleshooting, and routine maintenance of AKTA chromatography systems and related equipment.
- Ensure robust and reproducible downstream processes through detailed process monitoring and analysis.
- Analyze complex data sets, document experimental results comprehensively, and communicate findings clearly through written reports and presentations.
- Engage in global collaboration requiring international travel for technology transfer and project meetings.
- Stay current with scientific advancements and integrate innovative downstream processing technologies into existing workflows.
- Conduct evaluations of new technologies, assessing their potential impacts on operations and business objectives.
- Provide mentorship, training, and supervision to junior staff, fostering their technical and professional development.
- Assist in resource planning, budgeting, and project management to meet strategic goals and timelines.
- Promote rigorous adherence to safety standards, laboratory practices, and GMP regulations.
Qualifications:
- Ph.D., Master’s, or Bachelor’s degree in biochemistry, biochemical engineering, chemical engineering, or related discipline.
- Ph.D. with ≥2 years, Master’s with ≥5 years, or Bachelor’s with ≥8 years of experience in downstream bioprocess development and GMP scale-up.
- Demonstrated expertise in chromatography techniques (ion exchange, affinity, hydrophobic interaction, mixed-mode), filtration methods (TFF, viral clearance), and protein formulation.
- Hands-on proficiency with AKTA purification systems and troubleshooting equipment.
- Proficiency in protein analytical methods such as HPLC, SDS-PAGE, ELISA, and mass spectrometry.
- Experience in design-of-experiment (DOE) and statistical analysis software (JMP, Minitab, Design Expert).
- Strong analytical, organizational, and problem-solving skills.
- Excellent written and verbal communication skills, with demonstrated capacity for scientific reporting and presentations.
- Proven ability to manage multiple projects simultaneously in a dynamic environment.
- Highly collaborative with excellent teamwork skills.
- Client-focused, proactive, and driven by innovation and scientific excellence.
- Proficiency with Microsoft Office applications (Word, Excel, PowerPoint).
Senior Analytical Scientist
Position Summary:
Senior Analytical Scientists at Elise Biopharma lead critical analytical development efforts to ensure the robustness, accuracy, and regulatory compliance of biologics development. They are pivotal in supporting research, development, and manufacturing through advanced analytical methodologies and validation processes.
*Bilingual strongly preferred (French)
Responsibilities:
- Develop, validate, and execute complex analytical methodologies including chromatography, mass spectrometry, ELISA, and other bioanalytical assays.
- Lead analytical support for biologics characterization, stability testing, and quality control.
- Independently analyze, interpret, and report analytical results comprehensively and accurately.
- Collaborate extensively with international teams; international travel for project-related activities required.
- Maintain expertise on current analytical technologies and methods, evaluating and integrating new techniques into existing analytical platforms.
- Provide technical mentoring and supervision to junior scientists, fostering their professional growth.
- Actively participate in resource allocation, strategic planning, and timeline management for analytical development projects.
- Ensure strict compliance with laboratory safety standards, regulatory guidelines, and GMP practices.
Qualifications:
- Ph.D., Master’s, or Bachelor’s degree in analytical chemistry, biochemistry, pharmaceutical sciences, or a closely related discipline.
- Ph.D. with ≥2 years, Master’s with ≥5 years, or Bachelor’s with ≥8 years of experience in analytical development for biologics.
- Proven expertise in analytical method development and validation for biologics, including HPLC, LC-MS, ELISA, electrophoresis, and bioassays.
- Experience with regulatory documentation and submissions (FDA, EMA).
- Skilled in statistical and data analysis software (JMP, Minitab, Design Expert).
- Excellent organizational, analytical, and communication skills.
- Ability to manage multiple concurrent projects efficiently and effectively.
- Proficient with Microsoft Office suite (Word, Excel, PowerPoint).
- Demonstrated teamwork and collaboration skills, proactive attitude, and commitment to innovation.
- Flexible, results-oriented, and able to manage changing priorities effectively.
Senior Fermentation Scientist
Position Summary:
Senior Fermentation Scientists at Elise Biopharma lead innovative microbial fermentation projects, optimizing processes for recombinant protein production. They drive development and scale-up activities, mentor junior scientists, and collaborate closely with global teams.
Bilingual strongly preferred (French)
Travel required (>10%)
Responsibilities:
- Design, develop, and optimize microbial fermentation processes for recombinant proteins and other biologics.
- Operate, maintain, and troubleshoot fermentation equipment to ensure consistent and reliable processes.
- Execute experimental designs, thoroughly analyze complex datasets, document results, and communicate findings effectively through detailed reports and presentations.
- Collaborate with international teams, requiring frequent travel for project coordination and technology transfer.
- Stay current with scientific advancements, emerging fermentation technologies, and industry best practices.
- Lead evaluations and implementation of novel fermentation methodologies, enhancing operational efficiency and effectiveness.
- Provide mentorship, training, and supervision to junior team members, fostering their professional development and performance.
- Contribute actively to strategic planning, resource management, and project timelines.
- Ensure rigorous compliance with laboratory safety standards, GMP regulations, and environmental guidelines.
Qualifications:
- Ph.D., Master’s, or Bachelor’s degree in biochemical engineering, microbiology, biotechnology, or related field.
- Ph.D. with ≥2 years, Master’s with ≥5 years, or Bachelor’s with ≥8 years of hands-on experience in microbial fermentation development and scale-up.
- Proven expertise operating bench-scale and pilot-scale fermenters, optimizing microbial fermentation conditions.
- Strong understanding of microbial physiology, metabolism, and genetic manipulation relevant to fermentation processes.
- Proficiency in statistical design-of-experiment (DOE) software (e.g., JMP, Minitab, Design Expert).
- Familiarity with analytical methods relevant to fermentation (cell density, metabolite profiling, protein quantification).
- Excellent analytical, organizational, and troubleshooting skills.
- Strong written and oral communication skills, with demonstrated ability to prepare detailed technical reports and presentations.
- Ability to manage multiple complex projects concurrently in a dynamic environment.
- Proven leadership and collaborative capabilities within cross-functional teams.
- Proficiency in Microsoft Office applications (Word, Excel, PowerPoint).
- Flexibility and willingness to travel internationally.
Salary Range:
$160,000 – $200,000 annually, based on experience and qualifications.
Benefits:
- Comprehensive health insurance (medical, dental, vision)
- 401(k) with company matching
- Generous PTO and paid holidays
- Professional development and training opportunities
- Wellness program and on-site fitness facilities
Why Join Elise Biopharma?
- Innovative Environment: Work on cutting-edge technologies in biologics.
- Career Development: Continuous professional growth and training opportunities.
- Collaborative Culture: Be part of a dynamic team dedicated to scientific excellence.
Ready to make an impact? Apply now and become part of the Elise Biopharma journey. Email your CV or resume to [email protected] and our team will be in touch.